Hydrochloric Acid → HCID 70126387, compound

HRID 1068242Notes

Reaction equation

HRID 1068242 reaction equation
C([Cl:4])(=O)C.Cl.[CH2:6]([C:13]1[S:17][N:16]([CH:18]2[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)[CH2:15][N:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CO>[ClH:4].[CH2:6]([C:13]1[S:17][N:16]([CH:18]2[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH2:15][N:14]=1)[C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6367Acetyl chlorideHCID 131722702HCID 131722702, compound

Product 1

HCID 70126387HCID 70126387, compoundYield 121.4%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Acetyl chloride (0.2 mL, 2.8 mmol) was added to 2 mL of methanol and stirred for 10 min. This solution of HCl in methanol was added to 46 mg of 4-(5-benzyl-1,2,4-thiadiazol-2-yl)-1-t-butyoxycarbonyl-pieridine (step B) and stirred for 1 hr. The reaction mixture was concentrated and the residue was diluted with EtOAc and concentrated again to isolate 46 mg of the title compound which was sufficiently pure for use in the next step.

Workup

  1. stirringstirred for 1 hr
  2. concentrationThe reaction mixture was concentrated
  3. additionthe residue was diluted with EtOAc
  4. concentrationconcentrated again

Sources & evidence

ORD record
ord-015c4df4d599483e80fa9e957774c523
Source dataset
uspto-grants-2001_06
Patent number
US06248755B1

Reaction notes

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