Ethylamine → N-ethyl-2-fluorobenzamide

HRID 1068303Notes

Reaction equation

HRID 1068303 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH2:11]([NH2:13])[CH3:12]>C(Cl)Cl>[CH2:11]([NH:13][C:4](=[O:5])[C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[F:1])[CH3:12]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 98082-Fluorobenzoyl chloride

Product 1

HCID 3315690N-ethyl-2-fluorobenzamideYield 87.8%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-Fluorobenzoyl chloride (2 g, 12.6 mmol) and 70% aq ethyl amine (1.78 g, 27.7 mmol) were combined in CH2Cl2 according to General Method E1, and kugelrohr distilled to give 1.85 g of N-ethyl-2-fluorobenzamide as a colorless oil, an 87% yield.

Workup

  1. distillationdistilled

Sources & evidence

ORD record
ord-97d8af4143774d05b3208aaf4f206a1e
Source dataset
uspto-grants-2001_06
Patent number
US06248894B1

Reaction notes

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