HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-t-Butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine | HCID 21193300 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 4-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride | HCID 21193167 | — |
Reaction Steps
To a solution of N-t-butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine (0.546 mg, 1.87 mmol) in EtOAc (30 ml) at 0° C. was bubbled gasseous HCl until saturated. After 10 min the solvent was evaporated in vacuo to afford the title compound of sufficient purity to be used in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06248756B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-c632c0d9cb5f40bca51a3f24a84aaf96 |
| Source note | uspto-grants-2001_06 |