Hydrochloric Acid → 4-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride

HRID 1068396Notes

Reaction equation

HRID 1068396 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([CH3:21])[CH:16]=2)([OH:14])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>CCOC(C)=O>[ClH:22].[CH3:21][C:17]1[CH:16]=[C:15]([C:11]2([OH:14])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21193300N-t-Butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine

Product 1

HCID 211931674-(3-Methylphenyl)-4-hydroxypiperidine hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of N-t-butoxycarbonyl-4-(3-methylphenyl)-4-hydroxy piperidine (0.546 mg, 1.87 mmol) in EtOAc (30 ml) at 0° C. was bubbled gasseous HCl until saturated. After 10 min the solvent was evaporated in vacuo to afford the title compound of sufficient purity to be used in the next step.

Workup

  1. customAfter 10 min the solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-c632c0d9cb5f40bca51a3f24a84aaf96
Source dataset
uspto-grants-2001_06
Patent number
US06248756B1

Reaction notes

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