反应详情

温度

-78 °C

The product from Example 28, Step C is dissolved in THF and cooled to −78° C. under nitrogen. A solution of diisobutylaluminum hydride (1 eq.) in toluene is added dropwise. After 30 min, the reaction is quenched with saturated sodium potassium tartrate solution. The mixture is extracted with ethyl acetate, and the organic phase washed with saturated brine, and dried over MgSO4. Filtration and concentration provides the title compound

1. customthe reaction is quenched with saturated sodium potassium tartrate solution
2. extractionThe mixture is extracted with ethyl acetate
3. washthe organic phase washed with saturated brine
4. dry with materialdried over MgSO4
5. filtrationFiltration and concentration