4-[2-{1-(Triphenylmethyl)-4-imidazolyl}ethenyl]-1-phenylpiperidine → 4-[2-{1-(Triphenylmethyl)-4-imidazolyl}ethyl]-1-phenylpiperidine

HRID 1068433Notes

Reaction equation

HRID 1068433 reaction equation
[C:1]1([C:7]([C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[N:8]2[CH:12]=[C:11]([CH:13]=[CH:14][CH:15]3[CH2:20][CH2:19][N:18]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)[CH2:17][CH2:16]3)[N:10]=[CH:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CO.[H][H].[Pd]>[C:33]1([C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][CH:15]3[CH2:20][CH2:19][N:18]([C:21]4[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=4)[CH2:17][CH2:16]3)[N:10]=[CH:9]2)[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=1

Participants

5

Reactant 1

HCID 702432004-[2-{1-(Triphenylmethyl)-4-imidazolyl}ethenyl]-1-phenylpiperidine

Product 1

HCID 211933604-[2-{1-(Triphenylmethyl)-4-imidazolyl}ethyl]-1-phenylpiperidine

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 178418361HCID 178418361, compoundSolvent

Procedure

The product from Step E is dissolved in methanol and hydrogenated at 60 psi hydrogen with 10% palladium on carbon. When reaction is complete, the catalyst is filtered and the title compound obtained after evaporation of solvent.

Workup

  1. customWhen reaction
  2. filtrationthe catalyst is filtered

Sources & evidence

ORD record
ord-86bf265c70d24327a721fe7e3912c0a6
Source dataset
uspto-grants-2001_06
Patent number
US06248756B1

Reaction notes

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