Hydrochloric Acid → Ethyl 4-[3-(methanesulfonylamino-methyl)benzyl]piperidine-4-carboxylate hydrochloride salt

HRID 1068448Notes

Reaction equation

HRID 1068448 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]([CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([CH2:26][NH:27][S:28]([CH3:31])(=[O:30])=[O:29])[CH:21]=2)([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:32]>ClCCl>[ClH:32].[CH3:31][S:28]([NH:27][CH2:26][C:22]1[CH:21]=[C:20]([CH:25]=[CH:24][CH:23]=1)[CH2:19][C:11]1([C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1)(=[O:29])=[O:30]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70204744Ethyl N-tert-butoxycarbonyl-4-[3-(methane-sulfonylaminomethyl)benzyl]piperidine-4-carboxylate

Product 1

HCID 21193259Ethyl 4-[3-(methanesulfonylamino-methyl)benzyl]piperidine-4-carboxylate hydrochloride salt

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of ethyl N-tert-butoxycarbonyl-4-[3-(methane-sulfonylaminomethyl)benzyl]piperidine-4-carboxylate (270 mg) in dichloromethane (40 mL) at 0° C. was saturated with hydrogen chloride gas. The resultant solution was sealed with a rubber septum and stirred at room temp. for 2.5 h. The product solution was concentrated under vacuum to provide the title compound

Workup

  1. customat 0° C.
  2. concentrationThe product solution was concentrated under vacuum

Sources & evidence

ORD record
ord-210d9cbd573248bdbee4c3013e505927
Source dataset
uspto-grants-2001_06
Patent number
US06248756B1

Reaction notes

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