6-[3-(2-benzyloxyethoxy)-4-methoxyphenyl]-3,4,5,6-tetrahydro-2H-1,3-oxazin-2-one → 6-(3-cyclopentyloxy-4-methoxyphenyl)-5,5-dimethyl-3,4,5,6-tetrahydro-2H-1,3-oxazin-2-one

Participants

Reaction Steps

According to the same procedure as in Example 1(2) to (3), using 3-(3-cyclopentyloxy-4-methoxyphenyl)-2,2-dimethyl-3-hydroxypropiononitrile instead of 3-(3,4-dimethoxyphenyl)-3-hydroxypropiononitrile, the above-described compound (yield 54.3%) was obtained as a colorless oil.

Provenance & Evidence