HCID 21189701, compound → HCID 21189815, compound

HRID 1068583Notes

Reaction equation

HRID 1068583 reaction equation
[CH2:1]([O:8]CCOC1C=C(C2OC(=O)NCC2)C=CC=1OC)C1C=CC=CC=1.[CH3:27][C:28]([CH3:51])([CH:31]([OH:50])[C:32]1[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([O:40][CH:41]2[CH2:49][C:48]3[C:43](=[CH:44][CH:45]=[CH:46][CH:47]=3)[CH2:42]2)[CH:33]=1)[C:29]#[N:30]>>[CH3:27][C:28]1([CH3:51])[CH:31]([C:32]2[CH:37]=[CH:36][C:35]([O:38][CH3:39])=[C:34]([O:40][CH:41]3[CH2:49][C:48]4[C:43](=[CH:44][CH:45]=[CH:46][CH:47]=4)[CH2:42]3)[CH:33]=2)[O:50][C:1](=[O:8])[NH:30][CH2:29]1

Participants

3

Reactant 2

HCID 21189701HCID 21189701, compoundHCID 21189766HCID 21189766, compound

Product 1

HCID 21189815HCID 21189815, compoundYield 75.9%

Procedure

According to the same procedure as in Example 1(2) to (3), using 2,2-dimethyl-3-hydroxy-3-[3-(2-indanyloxy)-4-methoxyphenyl]propiononitrile instead of 3-(3,4-dimethoxyphenyl)-3-hydroxypropiononitrile, the above-described compound (yield 75.9%) was obtained as an off white solid.

Sources & evidence

ORD record
ord-40252f1378344ceda393f24b8a589e41
Source dataset
uspto-grants-2001_06
Patent number
US06251897B1

Reaction notes

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