Potassium tert-butoxide → HCID 136436908, compound

HRID 1068667Notes

Reaction equation

HRID 1068667 reaction equation
[CH3:1][C:2](C)([O-:4])[CH3:3].[K+].[CH2:7]([C:9]1[N:10]([CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][N:41]=2)[N:11]=[C:12]2[C:17](=[O:18])[NH:16][C:15]([C:19]3[C:20](OCCC)=[N:21][CH:22]=[C:23]([S:25]([N:28]4[CH2:33][CH2:32][N:31]([CH3:34])[CH2:30][CH2:29]4)(=[O:27])=[O:26])[CH:24]=3)=[N:14][C:13]=12)[CH3:8]>CC(O)C>[CH2:7]([C:9]1[N:10]([CH2:39][C:40]2[CH:45]=[CH:44][CH:43]=[CH:42][N:41]=2)[N:11]=[C:12]2[C:17](=[O:18])[NH:16][C:15]([C:19]3[C:20]([O:4][CH:2]([CH3:3])[CH3:1])=[N:21][CH:22]=[C:23]([S:25]([N:28]4[CH2:33][CH2:32][N:31]([CH3:34])[CH2:30][CH2:29]4)(=[O:26])=[O:27])[CH:24]=3)=[N:14][C:13]=12)[CH3:8]

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 136436909HCID 136436909, compound

Product 1

HCID 136436908HCID 136436908, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Potassium t-butoxide (290 mg, 2.60 mmol) was added to a stirred solution of the title compound of Example 20 (239 mg, 0.43 mmol) in propan-2-ol (7 ml) under nitrogen and the reaction mixture heated under reflux for 48 hours, then allowed to cool. The resulting mixture was evaporated under reduced pressure and the residue partitioned between water (20 ml) and ethyl acetate (20 ml).

Workup

  1. temperaturethe reaction mixture heated
  2. temperatureunder reflux for 48 hours
  3. temperatureto cool
  4. customThe resulting mixture was evaporated under reduced pressure
  5. customthe residue partitioned between water (20 ml) and ethyl acetate (20 ml)

Sources & evidence

ORD record
ord-ed5058f89cdb41e4ba33326496a03095
Source dataset
uspto-grants-2001_06
Patent number
US06251904B1

Reaction notes

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