Hydrochloric Acid → HCID 21190223, compound

HRID 1068720Notes

Reaction equation

HRID 1068720 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:23](=[O:24])[C:22]2[N:25]3[C:15](=[CH:16][N:17]=[C:18]3[CH:19]=[CH:20][CH:21]=2)[C:14]1=[O:26])=O)(C)(C)C.[ClH:27]>CO>[ClH:27].[ClH:27].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][N:13]1[C:23](=[O:24])[C:22]2[N:25]3[C:15](=[CH:16][N:17]=[C:18]3[CH:19]=[CH:20][CH:21]=2)[C:14]1=[O:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190077HCID 21190077, compound

Product 1

HCID 21190223HCID 21190223, compoundYield 99.1%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3.58 g (10.0 mmol) of 4,5-dihydro-4-[4-(tert-butoxycarbonylamino)butan-1-yl]-3H-1,4,8b-triazaacenaphthylene-3,5-dione in 30 ml of methanol was added 15 ml of conc. HCl. The mixture was stirred for one hour at room temperature. The solvent was distilled off. To the residue were added ethanol and ether. The resulting precipitate was collected by filtration and dried to give 3.28 g of the desired compound (99.1%, white solid), m.p.250.0-252.0° C.

Workup

  1. distillationThe solvent was distilled off
  2. additionTo the residue were added ethanol and ether
  3. filtrationThe resulting precipitate was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-8b417a2239cc4afb9fd6181c7b100e83
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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