Hydrochloric Acid → HCID 21190205, compound

HRID 1068722Notes

Reaction equation

HRID 1068722 reaction equation
[F:1][C:2]([F:27])([F:26])[CH2:3][S:4]([NH:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:22](=[O:23])[C:21]2[N:24]3[C:14](=[CH:15][N:16]=[C:17]3[CH:18]=[CH:19][CH:20]=2)[C:13]1=[O:25])(=[O:6])=[O:5].[ClH:28]>CO>[ClH:28].[F:27][C:2]([F:1])([F:26])[CH2:3][S:4]([NH:7][CH2:8][CH2:9][CH2:10][CH2:11][N:12]1[C:22](=[O:23])[C:21]2[N:24]3[C:14](=[CH:15][N:16]=[C:17]3[CH:18]=[CH:19][CH:20]=2)[C:13]1=[O:25])(=[O:6])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190206HCID 21190206, compound

Product 1

HCID 21190205HCID 21190205, compoundYield 90.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 440 mg (1.09 mmol) of 4,5-dihydro-4-[4-[(2,2,2-trifluoro)ethanesulfonamido]butan-1-yl]-3H-1,4,8b-triazaacenaphthylene-3,5-dione in 20 ml of methanol was added 0.15 ml of conc. HCl, and the solvent was distilled off. To the residue was added acetone, and the resulting solid product was collected by filtration, followed by washing with acetone and drying to give 435 mg of the desired compound (90.6%, colorless solid), m.p.154.0-155.0° C.

Workup

  1. distillationthe solvent was distilled off
  2. additionTo the residue was added acetone
  3. filtrationthe resulting solid product was collected by filtration
  4. washby washing with acetone
  5. customdrying

Sources & evidence

ORD record
ord-df5dd68fd44b4808a4d74035bf18db48
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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