Hydrochloric Acid → 4,5-Dihydro-4[5-(amino)pentan-1-yl]-3h-1,4,8b-triazaacenaphthylen-5-one.dihydrochloride

HRID 1068725Notes

Reaction equation

HRID 1068725 reaction equation
C(OC([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:14]1[C:24](=[O:25])[C:23]2[N:26]3[C:16](=[CH:17][N:18]=[C:19]3[CH:20]=[CH:21][CH:22]=2)[CH2:15]1)=O)(C)(C)C.[ClH:27]>C(O)C>[ClH:27].[ClH:27].[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][N:14]1[C:24](=[O:25])[C:23]2[N:26]3[C:16](=[CH:17][N:18]=[C:19]3[CH:20]=[CH:21][CH:22]=2)[CH2:15]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 211901734,5-Dihydro-4[5-(tert-butoxycarbonylamino)pentan-1-yl]-3H-1,4,8b-triazaacenaphthylen-5-one

Product 1

HCID 218465014,5-Dihydro-4[5-(amino)pentan-1-yl]-3h-1,4,8b-triazaacenaphthylen-5-one.dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 2.24 g (6.25 mmol) of 4,5-dihydro-4[5-(tert-butoxycarbonylamino)pentan-1-yl]-3H-1,4,8b-triazaacenaphthylen-5-one in 20 ml of ethanol was added 20 ml of conc. HCl. The mixture was stirred for 1.5 hour at room temperature. The solvent was distilled off to leave 2.05 g of the desired compound (quant. a pale brown solid). This product was used in the subsequent reaction without further purification.

Workup

  1. distillationThe solvent was distilled off

Sources & evidence

ORD record
ord-94b7f1198d414a29933569e98e947b9a
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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