Hydrochloric Acid → HCID 70211085, compound

HRID 1068730Notes

Reaction equation

HRID 1068730 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:5]2[C:6]=1[C:7](=[O:27])[N:8]3[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][S:20]([C:23]([F:26])([F:25])[F:24])(=[O:22])=[O:21].[ClH:28]>CO>[ClH:28].[CH3:1][C:2]1[N:3]=[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:5]2[C:6]=1[C:7](=[O:27])[N:8]3[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][NH:19][S:20]([C:23]([F:25])([F:24])[F:26])(=[O:22])=[O:21]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190231HCID 21190231, compound

Product 1

HCID 70211085HCID 70211085, compoundYield 83.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 623 mg (1.54 mmol) of 1,2-dihydro-3-methyl-1-[6-(trifluoromethanesulfonamido)hexan-1-yl]-1,4,7b-triazacyclopent[cd]inden-2-one in 10 ml of methanol was added 0.16 ml of conc. HCl and, then, the solvent was distilled off. To the residue were added acetone and ether. The resulting solid was washed with ether, dried to give 570 mg of the desired compound (83.9%, pale yellow solid).

Workup

  1. distillationthe solvent was distilled off
  2. additionTo the residue were added acetone and ether
  3. washThe resulting solid was washed with ether
  4. customdried

Sources & evidence

ORD record
ord-eeb77f72d9254141918148ba46b7192f
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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