Hydrochloric Acid → HCID 70213121, compound

HRID 1068733Notes

Reaction equation

HRID 1068733 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:5]2[C:6]=1[C:7](=[O:22])[N:8]3[CH2:13][CH2:14][CH2:15][CH2:16][NH:17][S:18]([CH3:21])(=[O:20])=[O:19].[ClH:23]>CO>[ClH:23].[CH3:1][C:2]1[N:3]=[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:5]2[C:6]=1[C:7](=[O:22])[N:8]3[CH2:13][CH2:14][CH2:15][CH2:16][NH:17][S:18]([CH3:21])(=[O:19])=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190079HCID 21190079, compound

Product 1

HCID 70213121HCID 70213121, compoundYield 99.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 500 mg (1.55 mmol) of 1,2-dihydro-3-methyl-1-[4-(methanesulfonamido)butan-1-yl]-1,4,7b-triazacyclopent[cd]inden-2-one in 20 ml of methanol was added 0.17 ml of conc. HCl. The solvent was then distilled off. The residue was washed with ether to give 555 mg of the desired compound (99.6%, colorless solid), m.p.166.0-167.0° C.

Workup

  1. distillationThe solvent was then distilled off
  2. washThe residue was washed with ether

Sources & evidence

ORD record
ord-b435098970d84b4381815bd0cb4c6b90
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

Loading…