Hydrochloric Acid → HCID 70213145, compound

HRID 1068744Notes

Reaction equation

HRID 1068744 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:5]2[C:6]=1[C:7]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][S:19]([C:22]([F:25])([F:24])[F:23])(=[O:21])=[O:20])=[N:8]3.[ClH:26]>CO>[ClH:26].[CH3:1][C:2]1[N:3]=[C:4]2[CH:12]=[CH:11][CH:10]=[C:9]3[N:5]2[C:6]=1[C:7]([S:13][CH2:14][CH2:15][CH2:16][CH2:17][NH:18][S:19]([C:22]([F:25])([F:23])[F:24])(=[O:20])=[O:21])=[N:8]3

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190213HCID 21190213, compound

Product 1

HCID 70213145HCID 70213145, compoundYield 79.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 873 mg (2.22 mmol) of 3-methyl-2-[4-(trifluoromethanesulfonamido)butan-1-ylthio]-1,4,7b-triazacyclopent[cd]indene in 10 ml of methanol was added 0.23 ml of conc. HCl. The solvent was then distilled off. The residue was recrystallized from ethanol-ether to give 762 mg of the desired compound (79.9%, colorless crystals), m.p.129.0-131.0° C.

Workup

  1. distillationThe solvent was then distilled off
  2. customThe residue was recrystallized from ethanol-ether

Sources & evidence

ORD record
ord-b39951bc348440e9b98a8328f63f9d03
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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