Hydrochloric Acid → HCID 70212384, compound

HRID 1068748Notes

Reaction equation

HRID 1068748 reaction equation
[F:1][C:2]([F:29])([F:28])[S:3]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]2[C:24](=[O:25])[C:23]3[N:26]4[C:16](=[CH:17][N:18]=[C:19]4[CH:20]=[CH:21][CH:22]=3)[C:15]2=[O:27])=[CH:9][CH:8]=1)(=[O:5])=[O:4].[ClH:30]>CO>[ClH:30].[F:28][C:2]([F:1])([F:29])[S:3]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([CH2:13][N:14]2[C:24](=[O:25])[C:23]3[N:26]4[C:16](=[CH:17][N:18]=[C:19]4[CH:20]=[CH:21][CH:22]=3)[C:15]2=[O:27])=[CH:9][CH:8]=1)(=[O:4])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54457528HCID 54457528, compound

Product 1

HCID 70212384HCID 70212384, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 129 mg (0.30 mmol) of 4,5-dihydro-4-[4-(trifluoromethanesulfonamido) phenylmethyl]-3H-1,4,8b-triazaacenaphthylene-3,5-dione in 10 ml of methanol was added 0.04 ml of conc. HCl. The solvent was distilled off. To the residue was added acetone. The resulting solid was washed with acetone and dried to afford 141 mg of the desired compound (100%, a pale brown solid).

Workup

  1. distillationThe solvent was distilled off
  2. additionTo the residue was added acetone
  3. washThe resulting solid was washed with acetone
  4. customdried

Sources & evidence

ORD record
ord-cc82c3653f934a59a6c323cc70f49f73
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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