Hydrochloric Acid → HCID 21190280, compound

HRID 1068749Notes

Reaction equation

HRID 1068749 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[C:25](=[O:26])[C:24]3[N:27]4[C:17](=[CH:18][N:19]=[C:20]4[CH:21]=[CH:22][CH:23]=3)[C:16]2=[O:28])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:29]>C(O)C>[ClH:29].[ClH:29].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][N:15]2[C:25](=[O:26])[C:24]3[N:27]4[C:17](=[CH:18][N:19]=[C:20]4[CH:21]=[CH:22][CH:23]=3)[C:16]2=[O:28])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190221HCID 21190221, compound

Product 1

HCID 21190280HCID 21190280, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a suspension of 7.99 g (20.8 mmol) of 4,5-dihydro-4-[1-(tert-butoxycarbonyl)piperidin-4-ylmethyl]-3H-1,4,8b-triazaacenaphthylene-3,5-dione in 50 ml of ethanol was added dropwise 25 ml of conc. HCl. The mixture was stirred for two hours at room temperature. The resulting crystalline precipitates were collected by filtration, washed with ethanol and then with ether to afford 7.07 g (87.4%, a colorless solid substance) of the desired compound

Workup

  1. customThe resulting crystalline precipitates
  2. filtrationwere collected by filtration
  3. washwashed with ethanol
  4. customwith ether to afford 7.07 g (87.4%

Sources & evidence

ORD record
ord-0c4b86c594c640e08a998c02ad66ba66
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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