反应详情

To a solution of 275 mg (1.00 mmol) of 3-methyl-2-[5-(amino)pentan-1-ylthio]-1,4,7b-triazacyclopent[cd]indene in 30 ml of acetonitrile were added 0.19 ml (1.36 mmol) of triethylamine and 171 mg (1.20 mmol) of ethyl ester of trifluoroacetic acid. The mixture was stirred for 15 hours at room temperature. The solvent was distilled off. To the residue was added ethyl acetate, which was washed with water, and dried over anhydrous magnesium sulfate. The solvent was distilled off, and the residue was purified by column chromatography (eluent: ethyl acetate) to afford 267 mg (72.0%, a pale yellow solid) of the desired compound.

1. distillationThe solvent was distilled off
2. additionTo the residue was added ethyl acetate, which
3. washwas washed with water
4. dry with materialdried over anhydrous magnesium sulfate
5. distillationThe solvent was distilled off
6. customthe residue was purified by column chromatography (eluent: ethyl acetate)
7. customto afford 267 mg (72.0%