Hydrochloric Acid → HCID 21190216, compound

HRID 1068770Notes

Reaction equation

HRID 1068770 reaction equation
[F:1][C:2]([F:29])([F:28])[S:3]([NH:6][CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:25][C:24]3[N:26]4[C:17](=[CH:18][N:19]=[C:20]4[CH:21]=[CH:22][CH:23]=3)[C:16]2=[O:27])=[CH:11][CH:10]=1)(=[O:5])=[O:4].[ClH:30]>C(O)C>[ClH:30].[F:28][C:2]([F:1])([F:29])[S:3]([NH:6][CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][C:12]([N:15]2[CH2:25][C:24]3[N:26]4[C:17](=[CH:18][N:19]=[C:20]4[CH:21]=[CH:22][CH:23]=3)[C:16]2=[O:27])=[CH:13][CH:14]=1)(=[O:4])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190065HCID 21190065, compound

Product 1

HCID 21190216HCID 21190216, compoundYield 69.4%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 85 mg (0.2 mmol) of 4,5-dihydro-4-[4-(2-trifluoromethanesulfonamidoethan-1-yl)phenyl]-3H-1,4,8b-triazaacenaphthylen-3-one in 5.0 ml of ethanol was added 0.04 ml (0.5 mmol) of 12N HCl. The mixture was stirred at room temperature, and concentrated under reduced pressure. The resulting precipitates were collected by filtration, and washed with a small volume of ethanol and ether to afford 64 mg of the desired compound (69.4%, a pale yellow solid).

Workup

  1. concentrationconcentrated under reduced pressure
  2. customThe resulting precipitates
  3. filtrationwere collected by filtration
  4. washwashed with a small volume of ethanol and ether

Sources & evidence

ORD record
ord-3db33270d9fe43198dcd7a56ffcaba66
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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