反应详情

To a solution of 3.65 g (9.85 mmol) of 1-[1-(tert-butoxycarbonyl)piperidin-4-ylmethyl]-1,2-dihydro-3-methyl-1,4,7b-triazacyclopent[cd]inden-2-one in 30 ml of methanol was added 15 ml of conc. HCl. The mixture was stirred for 1.5 hours at room temperature. The solvent was distilled off. To the residue was added chloroform and 2N agueous solution of sodium hydroxide to make alkaline. The mixture was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate. The solvent was distilled off to give 2.316 g of the desired compound (86.9%, pale yellow solid). This product was used in the subsequent reaction without further purification.

1. distillationThe solvent was distilled off
2. additionTo the residue was added chloroform and 2N agueous solution of sodium hydroxide
3. extractionThe mixture was extracted with chloroform
4. dry with materialThe extract was dried over anhydrous magnesium sulfate
5. distillationThe solvent was distilled off