Hydrochloric Acid → HCID 21190131, compound

HRID 1068773Notes

Reaction equation

HRID 1068773 reaction equation
[F:1][C:2]([F:27])([F:26])[S:3]([N:6]1[CH2:11][CH2:10][CH:9]([CH2:12][N:13]2[C:21]3[N:16]4[C:17](=[N:22][C:23]([CH3:24])=[C:15]4[C:14]2=[O:25])[CH:18]=[CH:19][CH:20]=3)[CH2:8][CH2:7]1)(=[O:5])=[O:4].[ClH:28]>CO>[ClH:28].[F:27][C:2]([F:1])([F:26])[S:3]([N:6]1[CH2:11][CH2:10][CH:9]([CH2:12][N:13]2[C:21]3[N:16]4[C:17](=[N:22][C:23]([CH3:24])=[C:15]4[C:14]2=[O:25])[CH:18]=[CH:19][CH:20]=3)[CH2:8][CH2:7]1)(=[O:4])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190132HCID 21190132, compound

Product 1

HCID 21190131HCID 21190131, compoundYield 97.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 494 mg (1.23 mmol) of 1,2-dihydro-1-[1-(trifluoromethanesulfonyl)piperidin-4-ylmethyl]-3-methyl-1,4,7b-triazacyclopent[cd]inden-2-one in 15 ml of methanol was added 0.13 ml of conc. HCl. The solvent was distilled off. The residue was treated with acetone and diethylether to give 526 mg of the desired compound (97.6%, colorless solid).

Workup

  1. distillationThe solvent was distilled off
  2. additionThe residue was treated with acetone and diethylether

Sources & evidence

ORD record
ord-76eb949914ab4988a9317d82e6bb327c
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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