Hydrochloric Acid → 1-[4-(Amino)butan-1-yl]-1,2-dihydro-1,4,7b-triazacyclopent[cd]inden-2-one-dihydrochloride

HRID 1068774Notes

Reaction equation

HRID 1068774 reaction equation
[NH:1]1[C:9]2[N:4]3[C:5](=[N:10][CH:11]=[C:3]3[C:2]1=[O:12])[CH:6]=[CH:7][CH:8]=2.[ClH:13]>CO>[ClH:13].[ClH:13].[NH2:1][CH2:9][CH2:8][CH2:7][CH2:6][N:1]1[C:9]2[N:4]3[C:5](=[N:10][CH:11]=[C:3]3[C:2]1=[O:12])[CH:6]=[CH:7][CH:8]=2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 117449051,2-Dihydro-1,4,7b-triazacyclopent[cd]inden-2-one

Product 1

HCID 702123701-[4-(Amino)butan-1-yl]-1,2-dihydro-1,4,7b-triazacyclopent[cd]inden-2-one-dihydrochlorideYield 79.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 548 mg (1.66 mmol) of 1-[4-tert-butoxycarbonylamino)butan-1-yl]-1,2-dihydro-1,4,7b-triazacyclopent[cd]inden-2-one in 10 ml of methanol was added dropwise 10 ml of conc. HCl. The mixture was stirred for one hour at room temperature. The solvent was distilled off. To the residue was added acetone. The resulting solid was collected by filtration and washed with acetone to give 400 mg of the desired compound (79.5%, grayish white solid).

Workup

  1. distillationThe solvent was distilled off
  2. additionTo the residue was added acetone
  3. filtrationThe resulting solid was collected by filtration
  4. washwashed with acetone

Sources & evidence

ORD record
ord-6471abc93b1e4222bf3d70dda429d0b6
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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