Hydrochloric Acid → HCID 21190282, compound

HRID 1068781Notes

Reaction equation

HRID 1068781 reaction equation
C(OC(N1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][N:17]2[C:25]3[N:20]4[C:21](=[N:26][CH:27]=[C:19]4[C:18]2=[O:28])[CH:22]=[CH:23][CH:24]=3)CC1)=O)(C)(C)C.[ClH:29]>C(O)C>[ClH:29].[ClH:29].[NH:17]1[CH2:18][CH2:13][CH:12]([CH2:11][CH2:14][CH2:15][CH2:16][N:17]2[C:25]3[N:20]4[C:21](=[N:26][CH:27]=[C:19]4[C:18]2=[O:28])[CH:22]=[CH:23][CH:24]=3)[CH2:15][CH2:16]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190070HCID 21190070, compound

Product 1

HCID 21190282HCID 21190282, compoundYield 84.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution prepared by dissolving 3.82 g (9.94 mM) of 1,2-dihydro-1-[3-(1-tert-butoxycarbonylpiperidin-4-yl)propan-1-yl]-1,4,7b-triazacyclopent[cd]inden-2-one in 50 ml of ethanol was added 10 ml (122 mM) of 12N-hydrochloric acid and the mixture was stirred at room temperature for 1 hour. After completion of the reaction, the reaction mixture was concentrated under reduced pressure and the resulting precipitate was recovered by filtration. The precipitate was rinsed with small amounts of ethanol and ether to provide 2.99 g (yield 84.5%) of the title compound as brown solid.

Workup

  1. customTo a solution prepared
  2. customAfter completion of the reaction
  3. concentrationthe reaction mixture was concentrated under reduced pressure
  4. filtrationthe resulting precipitate was recovered by filtration
  5. washThe precipitate was rinsed with small amounts of ethanol and ether

Sources & evidence

ORD record
ord-4809920bf5184135bfdbdd69ed2f9bad
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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