Hydrochloric Acid → HCID 21190199, compound

HRID 1068783Notes

Reaction equation

HRID 1068783 reaction equation
[F:1][C:2]([F:27])([F:26])[S:3]([N:6]1[CH2:11][CH2:10][CH:9]([CH2:12][N:13]2[CH2:23][C:22]3[N:24]4[C:15](=[CH:16][N:17]=[C:18]4[CH:19]=[CH:20][CH:21]=3)[C:14]2=[O:25])[CH2:8][CH2:7]1)(=[O:5])=[O:4].[ClH:28]>C(O)C>[ClH:28].[F:27][C:2]([F:1])([F:26])[S:3]([N:6]1[CH2:11][CH2:10][CH:9]([CH2:12][N:13]2[CH2:23][C:22]3[N:24]4[C:15](=[CH:16][N:17]=[C:18]4[CH:19]=[CH:20][CH:21]=3)[C:14]2=[O:25])[CH2:8][CH2:7]1)(=[O:4])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190200HCID 21190200, compound

Product 1

HCID 21190199HCID 21190199, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution prepared by dissolving 580 mg (1.44 mM) of 4,5-dihydro-4-(1-trifluoromethanesulfonylpiperidin-4-ylmethyl)-3H-1,4,8b-triazaacenaphthylen-3-one in 10 ml of ethanol was added 0.24 ml (2.88 mM) of 12N-hydrochloric acid with stirring. The resulting solution was concentrated under reduced pressure and the precipitate was recovered by filtration. The precipitate was rinsed with a small amount of ether and dried in vacuo to provide 480 mg (yield 80.0%) of the title compound as white solid.

Workup

  1. customTo a solution prepared
  2. concentrationThe resulting solution was concentrated under reduced pressure
  3. filtrationthe precipitate was recovered by filtration
  4. washThe precipitate was rinsed with a small amount of ether
  5. customdried in vacuo

Sources & evidence

ORD record
ord-8683e88822e342ab867be00d722f088f
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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