Hydrochloric Acid → HCID 21190232, compound

HRID 1068787Notes

Reaction equation

HRID 1068787 reaction equation
[F:1][C:2]([F:26])([F:25])[C:3]([N:5]1[CH2:10][CH2:9][CH:8]([CH2:11][N:12]2[CH2:22][C:21]3[N:23]4[C:14](=[CH:15][N:16]=[C:17]4[CH:18]=[CH:19][CH:20]=3)[C:13]2=[O:24])[CH2:7][CH2:6]1)=[O:4].[ClH:27]>C(O)C>[ClH:27].[F:26][C:2]([F:1])([F:25])[C:3]([N:5]1[CH2:6][CH2:7][CH:8]([CH2:11][N:12]2[CH2:22][C:21]3[N:23]4[C:14](=[CH:15][N:16]=[C:17]4[CH:18]=[CH:19][CH:20]=3)[C:13]2=[O:24])[CH2:9][CH2:10]1)=[O:4]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190139HCID 21190139, compound

Product 1

HCID 21190232HCID 21190232, compoundYield 55.7%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution prepared by dissolving 540 mg (1.47 mM) of 4,5-dihydro-4-(1-trifluoroacetylpiperidin-4-yl-methyl)-3H-1,4,8b-triazaacenaphthylen-3-one in 10 ml of ethanol was added 0.24 ml (2.94 mM) of 12N-hydrochloric acid with stirring. The resulting solution was concentrated under reduced pressure and the precipitate that formed was recovered by filtration. The precipitate was rinsed with a small amount of ether and dried in vacuo to provide 330 mg (yield 55.7%) of the title compound as white solid.

Workup

  1. customTo a solution prepared
  2. concentrationThe resulting solution was concentrated under reduced pressure
  3. customthe precipitate that formed
  4. filtrationwas recovered by filtration
  5. washThe precipitate was rinsed with a small amount of ether
  6. customdried in vacuo

Sources & evidence

ORD record
ord-0e1b59727c3c458dae772db7284484ec
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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