Hydrochloric Acid → HCID 21190243, compound

HRID 1068821Notes

Reaction equation

HRID 1068821 reaction equation
C(OC([N:8]1[CH2:18][C:17]2[N:19]3[C:10](=[CH:11][N:12]=[C:13]3[CH:14]=[CH:15][CH:16]=2)[C:9]1=[O:20])=O)(C)(C)C.[ClH:21]>C(O)C>[ClH:21].[N:12]1[CH:11]=[C:10]2[N:19]3[C:17](=[CH:16][CH:15]=[CH:14][C:13]=13)[CH2:18][NH:8][C:9]2=[O:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21190252HCID 21190252, compound

Product 1

HCID 21190243HCID 21190243, compoundYield 76.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 95.7 mg (0.35 mmol) of 4,5-dihydro-4-(tert-butoxycarbonyl)-3H-1,4,8b-triazaacenaphthylen-3-one in 100 ml of ethanol was added 0.09 ml (1.05 mmol) of 12N HCl. The mixture was stirred for one hour at room temperature. The resulting crystalline precipitates were collected by filtration, washed with a small volume of ethanol and ether and dried to give 56.1 mg of the desired compound (76.4%, white solid).

Workup

  1. customThe resulting crystalline precipitates
  2. filtrationwere collected by filtration
  3. washwashed with a small volume of ethanol and ether
  4. customdried

Sources & evidence

ORD record
ord-8b1f0ecf0d4d49329ca2b8c87d244720
Source dataset
uspto-grants-2001_06
Patent number
US06251905B1

Reaction notes

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