3-Methyl-4-nitrobenzoic acid → HCID 20666664, compound

HRID 1068863Notes

Reaction equation

[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=O.[NH2:14][C@@H:15]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:16][OH:17]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([NH:14][C@@H:15]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:16][OH:17])=[O:7]

Participants

Reactant 2

HCID 183703-Methyl-4-nitrobenzoic acid

HCID 447213phenylalaninol, (S)-

Product 1

HCID 20666664HCID 20666664, compoundYield 82%

Procedure

5 g (27.6 mmol) of 3-methyl-4-nitrobenzoic acid were reacted with 4.2 g (27.6 mmol) of (S)-2-amino-3-phenyl-1-propanol by the method of procedure 3c. 7.1 g (82%) of the product were obtained.

Sources & evidence

ORD record: ord-e58541677e5b46f4ad1335e3ad0757f8
Source dataset: uspto-grants-2001_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06251917B1

Reaction notes

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