3-Methyl-4-nitrobenzoic acid → HCID 21190811, compound

HRID 1068866Notes

Reaction equation

HRID 1068866 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([OH:7])=O.[NH2:14][C@@H:15]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:16][OH:17]>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[C:5]([NH:14][CH:15]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[CH2:16][OH:17])=[O:7]

Participants

3

Reactant 2

HCID 183703-Methyl-4-nitrobenzoic acidHCID 447213phenylalaninol, (S)-

Product 1

HCID 21190811HCID 21190811, compoundYield 82%

Procedure

5 g (27.6 mmol) of 3-methyl-4-nitrobenzoic acid were reacted with (S)-2-amino-3-phenyl-1-propanol by the method of procedure 3c. 7.1 g (82%) of the product were obtained.

Sources & evidence

ORD record
ord-640c14a89317453cb1595fb4c974eb26
Source dataset
uspto-grants-2001_06
Patent number
US06251917B1

Reaction notes

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