Octanoyl chloride → HCID 178443825, compound

HRID 1068886Notes

Reaction equation

HRID 1068886 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[N:8][C:9]=2[NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[NH:4][N:3]=1.[C:19](Cl)(=[O:27])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26]>N1C=CC=CC=1.C(Cl)Cl>[Cl:18][C:14]1[CH:13]=[C:12]([NH:11][C:9]2[N:8]=[CH:7][N:6]=[C:5]3[NH:4][N:3]=[C:2]([NH:1][C:19](=[O:27])[CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[C:10]=23)[CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 8124Octanoyl chlorideHCID 178509242HCID 178509242, compound

Product 1

HCID 178443825HCID 178443825, compound

Reagents, catalysts & solvents 1

HCID 21875418Pyridine methylene chlorideSolvent

Procedure

Analogously to Example 1, 400 mg (1.53 mmol) of 3-amino-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine (see Step 1.6) in 8 ml of pyridine/methylene chloride 1:1 are reacted at 0° C. with 288 μl (1.68 mmol) of octanoic acid chloride to form 4-(3-chlorophenylamino)-3-octanoylamino-1H-pyrazolo[3,4-d]pyrimidine (18 hours RT): HPLC: tRet(grad20-100)=14.5; FAB-MS: (M+H)+=387.

Sources & evidence

ORD record
ord-00cde5a780e34eb7aacb5e7de5de669c
Source dataset
uspto-grants-2001_06
Patent number
US06251911B1

Reaction notes

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