Octanoyl chloride → HCID 178443825, compound

Participants

Reaction Steps

Analogously to Example 1, 400 mg (1.53 mmol) of 3-amino-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine (see Step 1.6) in 8 ml of pyridine/methylene chloride 1:1 are reacted at 0° C. with 288 μl (1.68 mmol) of octanoic acid chloride to form 4-(3-chlorophenylamino)-3-octanoylamino-1H-pyrazolo[3,4-d]pyrimidine (18 hours RT): HPLC: tRet(grad20-100)=14.5; FAB-MS: (M+H)+=387.

Provenance & Evidence