反应详情

20.0 g (0.47 mol) of lithium chloride and 20.5 g (0.315 mol) of sodium azide are added to 41.2 9 (0.315 mol) of 4-cyano-benzaldehyde in 310 ml of methoxy-ethanol and the mixture is heated at boiling for 6 hours (argon atmosphere). When cool the reaction mixture is poured into 1 liter of ice/HCl 37% (10:1) and stirred thoroughly to complete the reaction. Filtration and washing with water yield 4-(tetrazol-5-yl)-benzaldehyde; m.p. 180-182° C.

1. temperaturethe mixture is heated
2. temperatureWhen cool the reaction mixture
3. customthe reaction
4. filtrationFiltration
5. washwashing with water