反应详情

A mixture of 145.4 g (422 mmol) of 3-[3-(N-Boc-aminomethyl)-phenylamino]-2-cyano-3-methylmercapto-acrylonitrile, 21.96 ml (443 mmol) of hydrazine hydrate and 1000 ml of methanol is heated under reflux for 2 hours and then concentrated by evaporation in vacuo, yielding 5-amino-[3(N-Boc-aminomethyl)-phenylamino]4-cyano-pyrazole; TLC-Rf=0.28 (methylene chloride/methanol [9:1]).

1. temperatureis heated
2. temperatureunder reflux for 2 hours
3. concentrationconcentrated by evaporation in vacuo