反应详情

温度

20 °C

15 g (36.25 mmol) of 3-[2-(Boc-amino)-ethylamino]-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine (water content: 2.39%; see Example 105) are dissolved in 250 ml of 3N methanolic hydrochloric acid and the reaction mixture is stirred at 20° C. for 18 hours. Subsequent filtration and washing the filter residue with methanol and diethyl ether yield 3-(2-aminoethylamino)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine dihydrochloride having a water content of 3.31%; m.p.>260° C.

1. filtrationSubsequent filtration
2. washwashing the filter residue with methanol and diethyl ether