反应详情

With intensive stirring, 35 ml of a saturated aqueous sodium carbonate solution and then 75 ml of ethyl acetate are added to a solution of 9.8 g (25.15 mmol) of 3-(2-amino-ethylamino)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine dihydrochloride (water content: 3.31%; see Example 106) in 100 ml of water, the desired product precipitating in crystalline form. Filtration and washing the filter residue with ethyl acetate yield 3-(2-amino-ethylamino)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine having a water content of 0.48%; m.p. 200° C.

1. customthe desired product precipitating in crystalline form
2. filtrationFiltration
3. washwashing the filter residue with ethyl acetate