Ammonium Hydroxide → HCID 10136238, compound

HRID 1069002Notes

Reaction equation

HRID 1069002 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[C:18]3[C:13](=[CH:14][CH:15]=[C:16]([NH:19][C:20]4[C:21](=O)[C:22](=[O:27])[C:23]=4[O:24]CC)[CH:17]=3)[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.[OH-].[NH4+:30]>C(O)C>[NH2:30][C:21]1[C:22](=[O:27])[C:23](=[O:24])[C:20]=1[NH:19][C:16]1[CH:17]=[C:18]2[C:13](=[CH:14][CH:15]=1)[N:12]=[CH:11][N:10]=[C:9]2[NH:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[CH:3]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 10160368HCID 10160368, compound

Product 1

HCID 10136238HCID 10136238, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 0.8 g of 3-[4-(3-Bromo-phenylamino)-quinazolin-6-ylamino]-4-ethoxy-cyclobut-3-ene-1,2-dione, 8 mL of ammonium hydroxide, and 8 mL of ethanol was refluxed for 1 hr. The mixture was cooled to room temperature and the solid was collected and washed with ethanol and ether giving 0.65 g of 3-Amino-4-[4-(3-bromo-phenylamino)-quinazolin-6-ylamino]-cyclobut-3-ene-1,2-dione as a yellow powder: mass spectrum (m/e): M+H 412.1.

Workup

  1. temperaturewas refluxed for 1 hr
  2. customthe solid was collected
  3. washwashed with ethanol and ether giving 0.65 g of 3-Amino-4-[4-(3-bromo-phenylamino)-quinazolin-6-ylamino]-cyclobut-3-ene-1,2-dione as a yellow powder

Sources & evidence

ORD record
ord-63e97905899b430980bc5f918d743776
Source dataset
uspto-grants-2001_06
Patent number
US06251912B1

Reaction notes

Loading…