Butanethiol → HCID 77750276, compound

HRID 1069039Notes

Reaction equation

HRID 1069039 reaction equation
[OH:1][CH2:2][CH2:3][CH:4]1[CH2:8][CH:7]([N:9]2[C:13]3[N:14]=[C:15]([S:28][CH3:29])[N:16]=[C:17]([NH:18][CH:19]4[CH2:21][CH:20]4[C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[C:12]=3[N:11]=[N:10]2)[CH:6]([OH:30])[CH:5]1[OH:31].[CH2:32](S)[CH2:33][CH2:34]C>>[CH2:29]([S:28][C:15]1[N:16]=[C:17]([NH:18][CH:19]2[CH2:21][CH:20]2[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[C:12]2[N:11]=[N:10][N:9]([CH:7]3[CH2:8][CH:4]([CH2:3][CH2:2][OH:1])[CH:5]([OH:31])[CH:6]3[OH:30])[C:13]=2[N:14]=1)[CH2:32][CH2:33][CH3:34]

Participants

3

Reactant 2

HCID 8012ButanethiolHCID 77750102HCID 77750102, compound

Product 1

HCID 77750276HCID 77750276, compound

Procedure

Prepared by the method of Example 4, step (b) using the product of Example 110, step a) and butanethiol then deprotected using the method of Example 1, step (b). Purification (HPLC, Novapak® C18 column, 0.1% aqueous ammonium acetate:acetonitrile, isocratic elution 45% MeCN over 30 minutes) afforded the title compound (210 mg).

Workup

  1. customPrepared by the method of Example 4, step (b)
  2. customPurification (HPLC, Novapak® C18 column, 0.1% aqueous ammonium acetate:acetonitrile, isocratic elution 45% MeCN over 30 minutes)

Sources & evidence

ORD record
ord-a45c08cb38604dd78e284a9340af3990
Source dataset
uspto-grants-2001_06
Patent number
US06251910B1

Reaction notes

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