HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-3'-[[2-[[2-(3-Chlorophenyl)-2-[[(tert-butyl)dimethylsilyl]oxy]ethyl][(tert-butoxy)carbonyl]amino]ethyl]amino]-[1,1'-biphenyl]-3,4-dicarboxylic acid dimethyl ester → (R)-3'-[[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-[1,1'-biphenyl]-3,4-dicarboxylic acid dimethyl ester dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-3'-[[2-[[2-(3-Chlorophenyl)-2-[[(tert-butyl)dimethylsilyl]oxy]ethyl][(tert-butoxy)carbonyl]amino]ethyl]amino]-[1,1'-biphenyl]-3,4-dicarboxylic acid dimethyl ester | HCID 69780599 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | (R)-3'-[[2-[[2-(3-Chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]-[1,1'-biphenyl]-3,4-dicarboxylic acid dimethyl ester dihydrochloride | HCID 69780650 | — |
Reaction Steps
Assay Found: C 55.03; H 5.36; N 5.04%; C26H27Cl1N2O5.0.64H2O requires C 55.04; H 5.38; N 4.94%; from (R)-3′-[[2-[[2-(3-chlorophenyl)-2-[[(tert-butyl)dimethylsilyl]oxy]ethyl][(tert-butoxy)carbonyl]amino]ethyl]amino]-[1,1′-biphenyl]-3,4-dicarboxylic acid dimethyl ester (1.1 g) in 4 N hydrochloric acid in dioxane (10 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06251925B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-8fbe6a29344a4554a628bd78de802669 |
| Source note | uspto-grants-2001_06 |