HCID 53719967, compound → HCID 69780937, compound

HRID 1069100Notes

Reaction equation

HRID 1069100 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:8]([O:35][Si](C(C)(C)C)(C)C)[CH2:9][N:10](C(OC(C)(C)C)=O)[CH2:11][CH2:12][NH:13][C:14]2[CH:15]=[C:16]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]#[N:27])[CH:21]=3)[CH:17]=[CH:18][CH:19]=2)[CH:5]=[CH:6][CH:7]=1>Cl.O1CCOCC1>[ClH:1].[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C@@H:8]([OH:35])[CH2:9][NH:10][CH2:11][CH2:12][NH:13][C:14]2[CH:15]=[C:16]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]#[N:27])[CH:21]=3)[CH:17]=[CH:18][CH:19]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 53719967HCID 53719967, compound

Product 1

HCID 69780937HCID 69780937, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

m.p. 191-206° C.; from (R)-3′-[[2-[[2-(3-chlorophenyl)-2-[[(tert-butyl)dimethylsilyl]oxy]ethyl][(tert-butoxy)carbonyl]amino]ethyl]amino]-[1,1′-biphenyl]-3-carbonitrile (173 mg) in 4 N hydrochloric acid in dioxane (10 mL).

Sources & evidence

ORD record
ord-ec4755a4e0474466b5585ca30dd8fa28
Source dataset
uspto-grants-2001_06
Patent number
US06251925B1

Reaction notes

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