Sodium Acetate → HCID 21191269, compound

HRID 1069123Notes

Reaction equation

HRID 1069123 reaction equation
[C:1]([C:4]1[CH:19]=[CH:18][C:7]([O:8][CH2:9][C:10]2[CH:11]=[C:12]([CH:15]=[CH:16][CH:17]=2)[CH:13]=O)=[C:6]([CH2:20][CH2:21][CH3:22])[C:5]=1[OH:23])(=[O:3])[CH3:2].[S:24]1[CH2:30][C:28](=[O:29])[NH:27][C:25]1=[S:26].C([O-])(=O)C.[Na+]>C(O)(=O)C>[C:1]([C:4]1[CH:19]=[CH:18][C:7]([O:8][CH2:9][C:10]2[CH:11]=[C:12](/[CH:13]=[C:30]3/[C:28](=[O:29])[NH:27][C:25](=[S:26])[S:24]/3)[CH:15]=[CH:16][CH:17]=2)=[C:6]([CH2:20][CH2:21][CH3:22])[C:5]=1[OH:23])(=[O:3])[CH3:2]

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 1201546RhodanineHCID 21191249HCID 21191249, compound

Product 1

HCID 21191269HCID 21191269, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Under a nitrogen atmosphere in a three-neck round bottom flask 3-[(4-acetyl-3-hydroxy-2-propylphenoxy)methyl]benzaldehyde (0.73 g, 2.34 mmol), rhodanine (0.34 g, 2.55 mmol), sodium acetate (0.23 g, 2.80 mmol) and acetic acid (20 ml) were combined and then heated to reflux. The reaction mixture was allowed to reflux. The progress of the reaction was monitored by thin layer chromatography.

Workup

  1. temperatureheated to reflux
  2. temperatureto reflux

Sources & evidence

ORD record
ord-613003df04e74d578ef94ae4d3448e0c
Source dataset
uspto-grants-2001_06
Patent number
US06251928B1

Reaction notes

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