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To a solution of 26.03 g (0.2 mol) of methyl propionylacetate in 300 ml of methanol, 100 ml of water and 35.12 g (0.22 mol) of benzyloxyamine hydrochloride, 19.69 g (0.24 mol) of potassium acetate were added and the mixture was stirred for 15 hours at room temperature. After distilling methanol off under reduced pressure, followed by adding 200 ml of water and extracting three times with 200 ml of ethyl acetate, the mixture was washed with water and a saturated aqueous sodium chloride and then dried over with anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain 47.06 g (yield: 100%) of a crude methyl 3-benzyloxyiminovalerate as a colorless oil.

1. distillationAfter distilling methanol off under reduced pressure
2. additionby adding 200 ml of water
3. extractionextracting three times with 200 ml of ethyl acetate
4. washthe mixture was washed with water
5. dry with materiala saturated aqueous sodium chloride and then dried over with anhydrous magnesium sulfate
6. distillationThe solvent was distilled off under reduced pressure