HCID 21191619, compound → benzyl 5-aminovalerate

HRID 1069256Notes

Reaction equation

HRID 1069256 reaction equation
C([NH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14])(OC(C)(C)C)=O>C(O)(C(F)(F)F)=O>[NH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[O:14]

Participants

3

Reactant 1

HCID 21191619HCID 21191619, compound

Product 1

HCID 7019821benzyl 5-aminovalerateYield 100.1%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

A mixture of benzyl N-Boc-5-aminovalerate (4 g) thus obtained in TFA (50 ml) was stirred at room temperature for 20 minutes. After the TFA was removed in vacuo, ethyl acetate and saturated aqueous sodium hydrogencarbonate were added. The separated ethyl acetate layer was dried over anhydrous sodium sulfate. The solvent was removed in vacuo to afford 2.7 g of benzyl 5-aminovalerate.

Workup

  1. customAfter the TFA was removed in vacuo, ethyl acetate and saturated aqueous sodium hydrogencarbonate
  2. additionwere added
  3. dry with materialThe separated ethyl acetate layer was dried over anhydrous sodium sulfate
  4. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-89a1626765de41edb3d44d684d70ae0c
Source dataset
uspto-grants-2001_06
Patent number
US06252041B1

Reaction notes

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