反应详情

Eight milliliters of acetonitrile and 2.13 ml (10 equivalents) of benzyl chloride were added to 0.758 g (1.85 mmols) of triacetylguanosine, and the mixture was reacted at 70° C. for 47 hours. The temperature was returned to room temperature, and 3.13 ml (20 equivalents) of conc. hydrochloric acid were added thereto. The reaction was conducted for 4 hours. After 2 hours of the reaction, the solid was precipitated. Ten grams of methanol were added thereto, and the slurry was stirred overnight, and then filtered. The crystals were washed twice with 5 ml of methanol, and dried at 50° C. under reduced pressure to give 0.456 g of 7-benzylguanine crystals in a yield of 78.5%.

1. customthe mixture was reacted at 70° C. for 47 hours
2. customwas returned to room temperature
3. customAfter 2 hours of the reaction
4. customthe solid was precipitated
5. additionTen grams of methanol were added
6. filtrationfiltered
7. washThe crystals were washed twice with 5 ml of methanol
8. customdried at 50° C. under reduced pressure