反应详情

178.7 g (1.4 mmol) of 4-hydroxy-6-methyl-2H-pyran-2-one are added, in portions at room temperature, to a solution of 106.4 g (1.4 mmol) of glycine in 1.4 l of a 1 N aqueous sodium hydroxide solution. The mixture is heated under reflux for 1 hour, the reaction medium is cooled and it is acidified with 500 ml of 3 N hydrochloric acid. The reaction medium is then concentrated to half the volume, the precipitate is filtered, it is washed with cold water and it is dried in an oven.

1. temperatureThe mixture is heated
2. temperatureunder reflux for 1 hour
3. temperaturethe reaction medium is cooled
4. concentrationThe reaction medium is then concentrated to half the volume
5. filtrationthe precipitate is filtered
6. washit is washed with cold water and it
7. customis dried in an oven