Benzyl chloroformate → HCID 70186513, compound

HRID 1069432Notes

Reaction equation

HRID 1069432 reaction equation
[NH2:1][C:2]1[C:3](=[O:22])[N:4]([CH2:17][C:18]([O:20][CH3:21])=[O:19])[C:5]([CH3:16])=[CH:6][C:7]=1[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1.Cl[C:24]([O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:25]>>[F:15][C:12]1[CH:13]=[CH:14][C:9]([CH2:8][C:7]2[CH:6]=[C:5]([CH3:16])[N:4]([CH2:17][C:18]([O:20][CH3:21])=[O:19])[C:3](=[O:22])[C:2]=2[NH:1][C:24]([O:26][CH2:27][C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[O:25])=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 10387Benzyl chloroformateHCID 70185216HCID 70185216, compound

Product 1

HCID 70186513HCID 70186513, compoundYield 83%

Procedure

1.8 g (5.91 mmol) of methyl 3-amino-4-[(4-fluorophenyl)methyl]-6-methyl-2-oxo-1,2-dihydro-pyridine-1-acetate are treated with 1 ml (7.09 mmol) of phenylmethyl chloroformate according to the method described in Example 3. The residue is purified by chromatography on a silica gel column, eluting with a dichloromethane:methanol (98:2) mixture. 2.15 g of product are obtained.

Workup

  1. customThe residue is purified by chromatography on a silica gel column
  2. washeluting with a dichloromethane:methanol (98:2) mixture

Sources & evidence

ORD record
ord-754c36790c2a48a4ad87f6fb4797a7cf
Source dataset
uspto-grants-2001_06
Patent number
US06252082B1

Reaction notes

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