(Iodomethyl)cyclohexane → Methyl 4-(cyclohexylmethyl)-6-methyl-3-nitro-2-oxo-1,2-dihydropyridine-1-acetate

HRID 1069435Notes

Reaction equation

HRID 1069435 reaction equation
[CH3:1][C:2]1[N:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[C:6](=[O:13])[C:5]([N+:14]([O-:16])=[O:15])=[C:4](OS(C(F)(F)F)(=O)=O)[CH:3]=1.[CH:25]1([CH2:31]I)[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[CH:25]1([CH2:31][C:4]2[CH:3]=[C:2]([CH3:1])[N:7]([CH2:8][C:9]([O:11][CH3:12])=[O:10])[C:6](=[O:13])[C:5]=2[N+:14]([O-:16])=[O:15])[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

3

Reactant 2

HCID 230414(Iodomethyl)cyclohexaneHCID 11079278Methyl 6-methyl-3-nitro-2-oxo-4-[[(trifluoromethyl)sulphonyl]oxy]-1,2-dihydropyridine-1-acetate

Product 1

HCID 86757065Methyl 4-(cyclohexylmethyl)-6-methyl-3-nitro-2-oxo-1,2-dihydropyridine-1-acetateYield 50.4%

Procedure

This compound is prepared from 3 g (8 mmol) of methyl 6-methyl-3-nitro-2-oxo-4-[[(trifluoromethyl)-sulphonyl]oxy]-1,2-dihydropyridine-1-acetate and 5.45 g (24.3 mmol) of cyclohexylmethyl iodide according to the method described in Example 1.5. 1.3 g of product are obtained in the form of yellow crystals.

Sources & evidence

ORD record
ord-ce66c34ac387473aa1ad3342ba4f2767
Source dataset
uspto-grants-2001_06
Patent number
US06252082B1

Reaction notes

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