Iodine chloride → 5-Chloro-7-iodo-2-methyl-8-quinolinol

HRID 1069531ノート

反応式

HRID 1069531 の反応式
[I:1]Cl.[Cl:3][C:4]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8]([CH3:15])=[N:9]2>CO>[Cl:3][C:4]1[CH:13]=[C:12]([I:1])[C:11]([OH:14])=[C:10]2[C:5]=1[CH:6]=[CH:7][C:8]([CH3:15])=[N:9]2

参加物

4

反応物 2

HCID 24640Iodine chloride2 回HCID 129451955-Chloro-2-methylquinolin-8-ol

生成物 1

HCID 183725885-Chloro-7-iodo-2-methyl-8-quinolinol収率 88%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Iodine monochloride (19.0 g) is added to a solution of 5-chloro-8-hydroxy-2-methylquinoline (21.5 g) in 250 mL of MeOH, and the resulting mixture is stirred for 3 h. Additional iodine monochloride (4.5 g) is then added, and the mixture is stirred for another 18 h. The reaction mixture is quenched with sat'd Na2SO3 (aq), then neutralized with sat'd NaHCO3 (aq). The solid precipitate is collected by filtration and dried under vacuum to give 31.22 g of the title compound as a pale green solid.

後処理

  1. stirringthe mixture is stirred for another 18 h
  2. customThe reaction mixture is quenched with sat'd Na2SO3 (aq)
  3. filtrationThe solid precipitate is collected by filtration
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-a084c8167c6b4c839510465f6916721d
出典データセット
uspto-grants-2001_06
特許番号
US06252080B1

反応ノート

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