HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Iodooctane → HCID 53772942, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Iodooctane | HCID 12380 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Ethyl (5-methoxy-2-methyl-1H-indol-3-yl)acetate | HCID 10729163 | — |
| Product | HCID 53772942 | HCID 53772942 | 51.5% |
Reaction Steps
Using the procedure described in Example 50, Part A, 2.47 g (0.01 mol) of 5-methoxy-2-methyl-1H-indole-3-acetic acid ethyl ester was reacted with 0.48 g (0.012 mol) of 60% NaH/mineral oil and then 2.17 mL (0.012 mol of iodooctane. The product was chromatographed on silica gel and eluted with 5% EtOAc/toluene to give 1.85 g (51% yield) of 5-methoxy-2-methyl-1-octyl-1H-indole-3-acetic acid ethyl ester as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06252084B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-a0b2dd99105f4b3f893c474cfc89ab4b |
| Source note | uspto-grants-2001_06 |