反应详情

[2-(tert-Butoxycarbonylamino)-5-methoxyphenyl] cyclopropyl ketone (13 g, 43 mmol) in 250 mL of CH2Cl2 and 25 mL of trifluoroacetic acid was stirred for 4 hours, washed with water, NaHCO3 solution, dried (Na2SO4) and concentrated at reduced pressure. The residue was chromatographed on silica (eluted with a gradient, toluene→20% EtOAc/hexane) to give 4.15 g (49% yield) of 2-cyclopropyl-5-methoxy-1H-indole as an oil.

1. washwashed with water, NaHCO3 solution
2. dry with materialdried (Na2SO4)
3. concentrationconcentrated at reduced pressure
4. customThe residue was chromatographed on silica (
5. washeluted with a gradient, toluene