HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (z)-1,3-Dihydro-5-fluoro-4-[(2s,4r)-(4-hydroxy-pyrrolidin-2-yl)-ethynyl]-3-[(3-methoxy-1h-pyrrol-2-yl)methylene]-2h-indol-2-one hydrochloride salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Dichloromethane methanol | HCID 21226129 | — |
| Reactant | (3Z)-5-fluoro-4-{2-[(2S,4R)-4-hydroxypyrrolidin-2-yl]ethynyl}-3-[(3-methoxy-1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one | HCID 23645083 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | (z)-1,3-Dihydro-5-fluoro-4-[(2s,4r)-(4-hydroxy-pyrrolidin-2-yl)-ethynyl]-3-[(3-methoxy-1h-pyrrol-2-yl)methylene]-2h-indol-2-one hydrochloride salt | HCID 69949280 | — |
Reaction Steps
A solution of (Z)-1,3-dihydro-5-fluoro-4-[(2S,4R)-(4-hydroxy-pyrrolidin-2-yl)-ethynyl]-3-[(3-methoxy-1H-pyrrol-2-yl)methylene]-2H-indol-2-one (30 mg, 0.06 mmol) (Example 99D above) in DMF (3 mL) was treated with aqueous HCl under vigorous stirring. The solution was lyophilized and the residue was perceipitated from a mixture of CH2Cl2/MeOH (3:1) with excess of pentanes. (Yield 30 mg, 91%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06252086B1 |
| Source dataset | uspto-grants-2001_06 |
| ORD ID | ord-882d5295c5ff4489ba047a076438aac2 |
| Source note | uspto-grants-2001_06 |